Nimez: [3rd-Party Driver] Amernime (NimeZ) AMD 22.3.2 WHQL Driver released : Amd

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Unique AMD WHQL Driver Tweaking Project

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A Driver Tweaking Project dedicated for Terascale DX11 (2 and 3), Legacy GCN (1, 2, 3), and Polaris/Vega/Navi. It’s not just INF tweaking, but «Finest» libraries selection from WU Driver Catalog to improve compatibility with newer games. Started the project in 2014 as little tweaks in Local Group Facebook «ASUS X550DP» formerly as Yamada Mods, aiming to keep unsupported GPU get latest compatibility hotfixes. A New way of Driver Tweaking without modifying driver source file while keeping WHQL Signature which required for Anti-Cheat based games or DRM Protection Apps.

Download Here:
Always check Release Notes and changes here:
Don’t panic if your gpu get name changes:
Get more info in Guru3D:


  • Unlocked Ryzen APU Relive
  • Unlocked RSR on RDNA Switchable Mobile
  • NimeZone Extra Switchable GPU Feature Mode Switch
  • NimeZone Split-Kernel Technology
  • NimeZone WHQL Parsing Technology
  • Possibility reduced total number of gpu driver crash even on latest official AMD supported GPU

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  • I cannot thank you enough!!! This drivers just gave a new life to my Anbernic Win600 handheld, i’ve got up to 10% increased FPS in games and while emulating Dolphin i can finally play GC/Wii at Full Speed (as opposed to 45fps before!).
    Thank you, this work is just amazing!

  • I need to know the tracks they use in the menu, I find myself opening this up just to listen.

  • V5-22.5.2-Rev3.0-UMD-PVN-WHQL-Nemesis-NimeZAdr-DCH.7z Driver installation failed on RX5500M. Error E0000219

  • Good devs and community

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User Interface

Win32 (MS Windows), Command-line


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Hosteria Cauquenes De Nimez, El Calafate – Updated 2022 Prices

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  • Info & prices
  • Facilities
  • House rules
  • The fine print
  • Guest reviews (109)

You’re eligible for a Genius discount at Hosteria Cauquenes De Nimez! To save at this property, all you have to do is sign in.

This cozy lodge offers panoramic views of the Argentinean Lake, the Round Bay and the Ecological Reserve Laguna Nimez. The rooms at Hosteria Cauquenes De Nimez feature free WiFi and a cable TV.

All rooms of Cauquenes De Nimez are equipped with a private bathroom, a work desk, and a safe.

Hosteria Cauquenes De Nimez has a tour desk which organizes several activities, such as horse riding, kayaking, hiking and bird watching. Guests can enjoy traditional Patagonian dishes in Cauquenes De Nimez’s restaurant. Complimentary tea service is provided in the afternoon.

It is only 701 m from Calafate’s main avenue, with its many shops, restaurants and bars. Free private parking is possible on site.

Hosteria Cauquenes De Nimez has been welcoming guests since Jun 14, 2010

Show me more

Most popular facilities

Free WiFi

Airport shuttle


Non-smoking rooms

24-hour front desk


Currency Exchange: Need local currency? This property has currency exchange on site.

Property Highlights

Continental, Vegetarian, Gluten-free, Buffet

Select dates to see this property’s availability and prices

Room Type



Standard Triple Room

3 twin beds


1 twin bed


1 full bed

Show prices

Standard Double/Twin Room

1 full bed


2 twin beds

Show prices

Superior Double Room

2 twin beds


1 full bed

Show prices

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Property questions and answers

Browse questions from guests for anything extra you want to know about the property

The property usually replies within a few days

  • Hello,
    My husband and I are interested in staying at your hotel. We will be driving our rental car from Puerto Natales to El Calafate to stay in El Calafate.
    Is there a ban on travelers driving their own rental car across the border between Chile and Argentina still?
    Thank you,

    Hello Natalia,
    could you give me a dates?

    Answered on November 21, 2022

  • Buenos Dias! Does the superior double room have a Mountain View? What is the difference between standard and superior? Gracias.

    the view of our rooms are, to the garden or to the street…The Argentinian Lake is just in front of our place…

    Answered on September 13, 2022

Area info *



    Open for:

Most popular facilities

Free WiFi

Airport shuttle


Non-smoking rooms

24-hour front desk



  • Toilet paper

  • Towels

  • Bidet

  • Bathtub or shower

  • Private Bathroom

  • Toilet

  • Free toiletries

  • Hairdryer

  • Shower


  • Linens

  • Wardrobe or closet


  • Picnic area

  • Outdoor furniture

  • Sun deck

  • Terrace

  • Garden


  • Bicycle rental
    Additional charge

  • Hiking
    Additional charge

  • Game room

  • Fishing
    Additional charge

Media & Technology

  • Flat-screen TV

  • Cable channels

  • TV

Food & Drink

  • Coffee house on site

  • Wine/Champagne
    Additional charge

  • Kids’ meals

  • Snack bar

  • Bar

  • Restaurant


WiFi is available in all areas and is free of charge.


No parking available.

Front Desk Services

  • Invoice provided

  • Concierge

  • Baggage storage

  • Tour desk

  • Currency exchange

  • 24-hour front desk

Cleaning Services

  • Daily housekeeping

  • Ironing service
    Additional charge

  • Dry cleaning
    Additional charge

  • Laundry
    Additional charge

Business Facilities

  • Fax/Photocopying
    Additional charge

Safety & security

  • Fire extinguishers

  • Safe


  • Shuttle service
    Additional charge

  • Shared lounge/TV area

  • Smoke-free property

  • Wake-up service

  • Heating

  • Car rental

  • Packed lunches

  • Airport shuttle
    Additional charge

  • Non-smoking rooms

  • Wake-up service/Alarm clock

  • Room service

  • Public Bath

  • Massage
    Additional charge

Languages Spoken

  • English

  • Spanish

  • French

  • Italian

House rules

Hosteria Cauquenes De Nimez takes special requests – add in the next step!


2:00 PM — 12:00 AM


6:00 AM — 10:00 AM


Cancellation and prepayment policies vary according to accommodations type.
Please enter the dates of your stay and check what conditions apply to your preferred room.

Children & Beds

Child policies

Children of all ages are welcome.

To see correct prices and occupancy info, add the number and ages of children in your group to your search.

Crib and extra bed policies

0 — 2 years

Crib upon request


The number of cribs allowed depends on the option you choose. Check your selected option for more info.

There are no extra beds available at this property.

All cribs are subject to availability.

No age restriction

There’s no age requirement for check-in


Pets are not allowed.

Cards accepted at this property

Hosteria Cauquenes De Nimez accepts these cards and reserves the right to temporarily hold an amount prior to arrival.

Legal info

This property is managed by a private host. EU consumer law relating to professional hosts might not apply.


NIMEZ: Instructions, reviews, analogues, price in pharmacies

  • Pharmacological properties
  • Indications for use
  • Method of application and dose
  • Side operations
  • Contraindications
  • Special instructions
  • overdose form of release, composition

Pharmacological properties


Nimesulide is well absorbed when administered orally, food intake does not affect the absorption capacity of nimesulide. Tmax is 1.2 — 3.3 hours when taken orally. Yd is 0.18 — 0.39l / kg, plasma protein binding is 95%. The maximum concentration of nimesulide in blood plasma reaches 3. 5 — 6.5 mg / l. Distribution volume: 0.19 — 0.35 l / kg. It penetrates into the tissues of the female genital organs, where, after a single dose, its concentration is about 40% of the plasma concentration. It penetrates well into the acidic environment of the focus of inflammation (40%), synovial fluid (43%). Easily penetrates through histo-hematic barriers. Metabolized in the liver by tissue monooxygenases. The main metabolite — 4-hydroxynimesulide (25%) has a similar pharmacological activity.

The half-life of nimesulide is 1.56 — 4.95 hours, 4-hydroxynimesulide — 2.89 — 4.78 hours. 4-hydroxynimesulide is excreted by the kidneys (65%) and bile (35%).

In patients with renal insufficiency (creatinine clearance 1.8-4.8 l / h or 30-80 ml / min), as well as in children and the elderly, the pharmacokinetic profile of nimesulide does not change significantly.


Nimez-100 is a non-steroidal anti-inflammatory drug with effective anti-inflammatory, antipyretic and analgesic properties. Chemically, Nimez-100 differs from other non-steroidal anti-inflammatory drugs in the presence of a sulfonanilide functional group in its structure. Nimez-100 is a selective inhibitor of prostaglandin synthesis due to inhibition of the cyclooxygenase-2 enzyme. It inhibits the enzyme type IV phosphodiesterase, which reduces the formation of superoxide by activating neutrophils without affecting phagocytic and chemotactic activity. Nimez-100 reduces the extracellular availability of hypochlorous acid formed during phagocytosis.

Nimez-100 also inhibits the release of histamine from basophils and mast cells, depending on the concentration, reduces the formation of platelet activating factor.

Nimez-100 reduces the destruction of cartilage by inhibiting the synthesis of metalloproteases such as collagenase and stromelysin. The drug controls the activity of the elastase enzyme in the site of inflammation, which provides an anti-inflammatory effect.

Indications for use

  • treatment of acute pain
  • symptomatic treatment of pain in osteoarthritis
  • primary dysmenorrhea

Nimez-100 should only be used as a second line drug.

The decision to treat with nimesulide should be based on an assessment of all risks for the individual patient.

Dosage and administration

Adults: 1 tablet (100 mg) orally 2 times a day. The maximum daily dose for adults is 200 mg. The duration of the course of treatment is not more than 5 days.

Tablets are taken with sufficient water, preferably before meals.

Side effects

common (≥ l/100, < l/10):

  • diarrhea, nausea, vomiting /100):

    • dizziness
    • hypertension
    • shortness of breath
    • constipation, flatulence, gastritis
    • itching, rash, excessive sweating
    • swelling

    Rarely (≥ l/10,000,

    • anemia, eosinophilia
    • increased sensitivity
    • hypercalemia
    • Feelings, nervous dreams
    • Clear vision 9000 9000 9000 9000 9000 tachycardia
    • hemorrhage, blood pressure lability, hot flashes
    • erythema, dermatitis
    • dysuria, hematuria, urinary retention
    • weakness, asthenia

    Very rarely (

    • thrombocytopenia, pantopenia, purple
    • anaphylaxis
    • Headache, drowsiness, encephalopathy (Reye Syndrome)
    • Visual vision
    • 9000 in the abdomen, dyspepsia, stomatitis, tarry stools, gastrointestinal bleeding, duodenal ulcer and perforation, gastric ulcer and perforation

    • hepatitis, fulminant hepatitis (including deaths), jaundice, cholestasis
    • urticaria, angioedema, facial edema, erythema of polyformation, Stevens-Johnson syndrome, toxic epidermal necrolysis
    • renal failure, oliguria, interstitial nephritis
    • hypothermia
    • increased sensitivity to nickelids or to one of the auxiliary substances drug
    • past hyperergic reactions (eg bronchospasm, rhinitis, urticaria) in connection with the use of acetylsalicylic acid or other non-steroidal anti-inflammatory drugs
    • history of hepatotoxic reactions to nimesulide in the past
    • concomitant use of other substances with potential hepatotoxicity
    • alcoholism, drug addiction
    • history of cerebrovascular bleeding or other hemorrhages, as well as diseases accompanied by bleeding
    • Serious blood coagulation violations
    • Serious heart failure
    • Serious renal failure (creatinine clearance  30 ml/min)
    • Patients of
    • Patients with colds or influenza
    • Hereditary fructose intolerance, malabsorption of glucose-galax -isomaltase
    • in liver diseases and elevated liver enzymes
    • children under 18 years of age
    • pregnancy and lactation

    Drug interactions

    Simultaneous use of nimesulide with corticosteroids, antiplatelet agents and selective serotonin reuptake inhibitors (SSRIs) increases the risk of gastrointestinal ulcers or bleeding.

    In patients using warfarin or similar anticoagulants, as well as acetylsalicylic acid, while using with nimesulide, there is an increased risk of bleeding. Therefore, this combination is not recommended, and in severe forms of bleeding disorders, it is contraindicated.

    If such a combination cannot be avoided, regular monitoring of the state of the blood coagulation system is necessary.

    Nimesulide may reduce the effect of diuretics and other antihypertensive drugs. In some patients with impaired renal function, the co-administration of nimesulide and ACE inhibitors, angiotensin II antagonists, or substances that suppress the cyclooxygenase system may further worsen renal function and cause acute renal failure, which, as a rule, is reversible. Therefore, the combined use of these drugs should be prescribed with caution, especially for elderly patients. Patients should be adequately hydrated and renal function should be closely monitored after initiation of combination therapy.

    In healthy volunteers, nimesulide can temporarily reduce the diuretic effect of furosemide and the excretion of sodium and, to a lesser extent, potassium, therefore, when using nimesulide and furosemide at the same time, patients with impaired renal or cardiac function should be especially careful. Co-administration of nimesulide and furosemide leads to a decrease (approximately 20%) in the area under the concentration-time curve (AUC) and a decrease in the cumulative excretion of furosemide without changing the renal clearance of furosemide.

    Nimesulide may decrease the clearance of lithium, resulting in increased plasma lithium levels and toxicity. When prescribing nimesulide to patients receiving lithium therapy, frequent monitoring of plasma lithium levels should be carried out.

    When used simultaneously with glibenclamide, theophylline, warfarin, digoxin, cimetidine and antacids, no clinically significant interactions were observed.

    Nimesulide inhibits CYP2C9 enzyme activity. While taking drugs that are substrates of this enzyme with nimesulide, the concentration of these drugs in plasma may increase.

    When prescribing nimesulide less than 24 hours before or less than 24 hours after taking methotrexate, caution is required, since in such cases the plasma level of methotrexate and, accordingly, the toxic effects of this drug may increase.

    Simultaneous use with cyclosporine may increase the nephrotoxicity of the latter.

    In vitro studies of have shown that nimesulide is displaced from binding sites by tolbutamide, salicylic acid and valproic acid. Despite the fact that these interactions were determined in blood plasma, these effects were not observed during the clinical use of the drug.

    During treatment with nimesulide, simultaneous use with drugs that have a hepatotoxic effect, as well as alcohol abuse, should be avoided, since these substances can increase the risk of adverse reactions from the liver.

    Special instructions

    The drug is not recommended for use as an antipyretic. With an increase in body temperature and the appearance of flu-like symptoms in patients receiving Nimez-100, the drug should be discontinued.

    To reduce the risk of side effects, it is necessary to use the drug in the minimum effective dose with the shortest duration of treatment. If the patient’s condition does not improve, treatment should be discontinued.

    Use in patients with impaired liver function

    In patients with severely impaired liver function, the metabolism of Nimez-100 is impaired, clearance decreases and the concentration of nimesulide in the blood increases, which can lead to accumulation of the drug. There are also reports of liver dysfunction occurring while taking Nimez-100, from moderate to severe, including fatal. Thus, Nimez-100 is not recommended for use in patients with liver disease.

    If patients taking Nimez-100 develop symptoms suggestive of liver damage (eg, anorexia, nausea, vomiting, abdominal pain, fatigue, dark urine) or abnormal liver function tests, the drug should be discontinued. Such patients are not recommended to prescribe Nimez-100 in the future.

    During treatment with Nimez-100, it is recommended to avoid the simultaneous use of hepatotoxic drugs, analgesics, other NSAIDs and alcohol.

    Use in patients with impaired renal function

    The drug should be used with caution in patients with impaired renal function (creatinine clearance less than 30 ml / min), since in such patients the half-life of nimesulide increases.

    Since Nimez-100 may affect platelet function, it should be used with caution in patients with hemorrhagic diathesis. However, Nimez-100 does not replace acetylsalicylic acid in the prevention of cardiovascular disease.

    Very rare cases of serious skin reactions to non-steroidal anti-inflammatory drugs have been reported, some of which can be fatal. Including exfoliative dermatitis, Stevens-Johnson syndrome and toxic epidermal necrosis. Patients are at a very high risk of such reactions if, with a previously prescribed course of treatment, the onset of the reaction in most cases occurred within the first month of treatment. Nimez-100 should be discontinued at the first sign of skin rash, mucosal lesions and other signs of an allergic reaction.

    Features of the effect of the drug on the ability to drive a vehicle or potentially dangerous mechanisms

    Considering the side effects of the drug, care should be taken when driving a vehicle or potentially dangerous mechanisms.


    Symptoms: drowsiness, nausea, vomiting, abdominal pain. Gastrointestinal bleeding, increased pressure, urinary retention, anaphylactic reactions, respiratory depression and coma are possible.

    Treatment: gastric lavage, activated charcoal, symptomatic therapy. There is no specific antidote.

    Form of release, composition

    Tablets, round shape with yellow biconvex surface.

    10 tablets are placed in a blister pack made of PVC film and aluminum foil. 1 contour pack, together with instructions for medical use in the state and Russian languages, is placed in a cardboard box.

    One tablet contains:

    active substance — nimesulide 100 mg,

    excipients: calcium hydrogen phosphate, corn starch, microcrystalline cellulose, sodium starch glycolate, anhydrous colloidal silicon dioxide, talc, magnesium stearate.

    Basic parameters

    Name: NIMES

    Nimesulide Analgesic Treatment of acute pain Treatment of pain

    contraindications, side effects, suspension; pills in the drug guide

    • Product description Nimez
    • Ingredients of Nimez
    • Indications for Nimez
    • Storage conditions for Nimez
    • Nimez
    • shelf life

    Marketing authorization holder:

    Active substance:

    ATX code: Musculoskeletal system (M) > Anti-inflammatory and antirheumatic drugs (M01) > Non-steroidal anti-inflammatory drugs (M01A) > Other non-steroidal anti-inflammatory drugs (M01AX) > Nimesulide (M01AX17)

    Clinical and pharmacological group: NSAIDs. Selective COX-2 inhibitor

    Release form, composition and packaging

    tab. 100 mg: 10 pcs.
    Ref. №: RK-LS-5-№ 010062 dated 06/18/2007 — Canceled

    1 tab.
    nimesulide 100 mg

    10 pcs. — packaging.

    susp. 50 mg/5 ml: vial. 60 ml
    Reg. No: RK-LS-5-No. 005607 dated 02/27/2007 — Canceled

    Suspension for oral administration.

    5 ml
    nimesulide 50 mg

    60 ml vials.

    Description of active ingredients of preparation NIMES . The provided scientific information is general and cannot be used to make a decision on the possibility of using a particular medicinal product. Date of update: 01/14/2006

    Pharmacological action

    NSAID containing a sulfonilide group in its structure. Nimesulide is believed to be a selective COX-2 inhibitor. It has a pronounced anti-inflammatory, as well as analgesic and, to a lesser extent, antipyretic effect. The mechanism of action is associated with inhibition of prostaglandin synthesis. Suppresses the synthesis of prostaglandins in the area of ​​inflammation to a greater extent than in the gastric mucosa or kidneys, due to inhibition of predominantly COX-2.

    In addition, in the mechanism of anti-inflammatory action of nimesulide, its ability to suppress the formation of free oxygen radicals (without affecting hemostasis and phagocytosis) and inhibit the release of the myeloperoxidase enzyme is important.


    After oral administration, nimesulide is well absorbed from the gastrointestinal tract, Cmax max in plasma is reached after 1-2 hours.

    Protein binding is 99%. After oral administration of a single dose of 100 mg, nimesulide is present in the tissues of the female genital organs at a concentration of 40% of the plasma concentration.

    Metabolized in the liver, the main metabolite hydroxynimesulide has pharmacological activity.

    T 1/2 from plasma is 2-3 hours.

    Excreted from the body mainly in the urine, about 98% of the dose is excreted within 24 hours. With prolonged therapy, cumulation of nimesulide is not observed.

    Indications for use

    Osteoarthritis, extra-articular rheumatic diseases, pain and inflammation after surgery, pain and fever in acute inflammatory processes in the upper respiratory tract, pain associated with dysmenorrhea.

    Dosage regimen

    Inside adults 100-200 mg 2 times / day, children — 1.5 mg / kg 2-3 times / day.

    The maximum dose of for children is 5 mg/kg/day in 2-3 divided doses.

    Side effects

    From the digestive system:

    heartburn, nausea, stomach pain;

  • in some cases — tarry stools, melena (associated with bleeding and erosive and ulcerative lesions of the gastrointestinal tract).
  • From the side of the central nervous system:

    rarely — headaches, dizziness, drowsiness.

    Allergic reactions:

    skin rash, erythema, urticaria.


    rarely — oliguria, fluid retention in the body, local or systemic edema;

  • in some cases — thrombocytopenic purpura.
  • Contraindications for use

    Peptic ulcer of the stomach and duodenum in the acute phase, acute bleeding from the gastrointestinal tract, moderate and severe liver failure, renal failure (CC less than 30 ml / min), pregnancy, lactation; hypersensitivity to nimesulide and other NSAIDs (including acetylsalicylic acid).

    Use during pregnancy and lactation

    Nimesulide is contraindicated for use during pregnancy and lactation.

    There are no direct indications of the embryotoxic and tocolytic effects of nimesulide.

    Use in hepatic impairment

    Contraindicated in moderate to severe hepatic impairment.

    Use in impaired renal function

    Contraindicated in renal failure (CC less than 30 ml/min).

    Use in elderly patients

    When used externally, a doctor’s supervision over the condition of elderly patients with impaired renal function, liver, congestive heart failure is required.

    Pediatric use

    For pediatric use, pediatric formulations should be used. In children under the age of 6 years, when using nimesulide externally, a doctor’s supervision is required.


    Caution should be taken orally in patients with impaired renal function, arterial hypertension, cardiac dysfunction, visual impairment.

    When used externally, a doctor’s supervision over the condition of elderly patients with impaired renal function, liver, congestive heart failure is required.

    For pediatric use, dosage forms intended for children should be used. In children under the age of 6 years, when using nimesulide externally, a doctor’s supervision is required.